Pharmacokinetic parameters of ethyl piperate after oral and intravenous administration in the hamster
For AUC(0–t), the value of t is defined as the last quantifiable point (1.5 and 4 h after oral and intravenous administration of ethyl piperate, respectively).
| Parameters | 30 mg/kg p.o. | 10 mg/kg i.v. |
|---|---|---|
| AUC(0–t) (μg/l · h) | 34.5 ± 51.6 | 2454.6 ± 489.1 |
| MRT(0–t) (h) | 0.40 ± 0.08 | 0.43 ± 0.09 |
| t1/2 (h) | N.A. | 0.63 ± 0.25 |
| Tmax (h) | 0.15 ± 0.11 | N.A. |
| CLz/F (l · h−1 · kg−1) | N.A. | 4.17 ± 0.77 |
| Vz/F (l/kg) | N.A. | 3.76 ± 1.57 |
| Cmax (μg/l) | 70.4 ± 93.4 | N.A. |
| F (%) | 0.47 |
MRT, mean retention time; Tmax, time to reach maximum concentration; Cmax, maximum concentration; CLZ/F, clearance; VZ/F, volume of distribution; N.A., not available.