TABLE 1

Kinetic parameters of T-5224 glucuronidation in pooled HLM and pooled HIM

Each value represents a best-fit value ± computer-calculated S.E. of triplicate points.

Protein Source	G2					G3
Protein Source	V_max	K_m	K_si	V_max/K_m	CL_int	V_max	K_m	K_si	V_max/K_m	CL_int
	pmol · min⁻¹ · mg protein⁻¹	μM	μM	μl · min⁻¹ · mg protein⁻¹	ml · min⁻¹ · kg⁻¹	pmol · min⁻¹ · mg protein⁻¹	μM	μM	μl · min⁻¹ · mg protein⁻¹	ml · min⁻¹ · kg⁻¹
HLM	217 ± 33	4.93 ± 1.22	13.2 ± 3.2	44.0	39.6	305 ± 47	15.7 ± 3.4	27.0 ± 6.9	19.5	17.5
HIM	241 ± 118	5.88 ± 3.69	2.64 ± 1.62	40.9	3.68	106 ± 18	3.06 ± 1.12	58.0 ± 27.1	34.6	3.12