Ae(bile, 0–6 h) (μmol) | 0.05 ± 0.05 | 0.09 ± 0.03 | 0.02 ± 0.01 | 1.7 ± 1.3 | 0.6 ± 0.4 | 0.8 ± 0.8a |
| 0.03 (0.002–0.12)b | 0.09 (0.05–0.13)b | 0.02 (0.01–0.04)b | 1.2 (0.7–3.9)b | 0.7 (0.05–1.3)b | 0.6 (0.06–1.65)b |
fbile (%) | 0.09 ± 0.09 | 0.18 ± 0.07 | 0.19 ± 0.10 | 3.1 ± 2.4 | 1.1 ± 0.8 | 5.5 ± 5.7 |
CLapp, bile (ml · min−1 · kg−1) | 0.009 ± 0.007 | 0.010 ± 0.004 | 0.014 ± 0.006 | 2.4 ± 1.3 | 1.2 ± 0.4 | 3.6 ± 3.4 |
AUCbile, 0–6 h (μM · h) | 2.5 ± 1.9 | 4.2 ± 2.0 | 1.1 ± 0.5 | 106 ± 63 | 27 ± 20 | 23 ± 20 |
Cmax (μM) | 1.3 ± 1.0 | 2.0 ± 0.9 | 0.5 ± 0.04 | 37 ± 25 | 9.5 ± 7.2 | 8.2 ± 9.3 |
AUCbile/AUCVPc | 0.9 ± 0.6 | 0.7 ± 0.3 | 0.9 ± 0.3 | 106 ± 74 | 104 ± 69 | 174 ± 134 |
AUCbile/AUCVHc | 14 ± 12 | 6 ± 3 | 7 ± 2 | 94 ± 67 | 69 ± 35 | 136 ± 103 |
Biliary flow (ml · min−1 · kg−1) | 0.010 ± 0.004 | 0.016 ± 0.008 | 0.015 ± 0.006 | | | |