Parameter | T1 | T2 |
---|---|---|
Vcent (liters) | 26a | 20b |
Vper (liters) | 11a | 11 |
Vgw (liters) | 0.25c | 0.25 |
Vliver (liters) | 2.8c | 2.8 |
Vpv (liters) | 9.4a,d | 9.4 |
k12 (l/h) | 1.8a | 1.8 |
k21 (l/h) | 2.8a | 2.8 |
kpv (l/h) | 12d,e | 12 |
kgl (l/h) | 6d,e | 6 |
Qh (l/h) | 45d,f | 45 |
fu | 0.17g | 0.17 |
CLr (l/h) | 0.0078g | 0.0078 |
Vmax gw (μM/h) | 10d,h | 10 |
Km (μM) | 2.5d,h | 2.5 |
Vmax (μM/h) | 387d,h | 387 |
fa | 1d,i | 1 |
Dose (μmol) | 54 | 54 |
Ki (μM) | 0.015j | |
Igw (μM) | 9k | |
Iliver (μM) | 6.5b | |
fuI | 0.01j |
cent, central; per, peripheral; gw, gut wall; pv, portal vein; gl, gut lumen. For detailed information, see the supplemental data online.
↵a Two-compartment analyses, intravenous data.
↵b Adjusted to improve the model in T2.
↵c Data from Zhang et al. (2009).
↵d Adjusted to improve the model in T1.
↵e Estimates from one-compartment analyses in T1.
↵f Nordgren et al. (2002).
↵g Measured in this study.
↵h Estimated from CL after intravenous administration and from Ishii et al. (1994).
↵i Data from Steiner et al. (1996).
↵j Data from Perdaems et al. (2010).
↵k Cmax for ketoconazole in this study in the VP.