TABLE 2 Fraction (percentage) of the compounds returning estimates enzyme kinetic variables (CLint, Vmax, and Km) with an expected error (RMSE) less than 10, 30, and 100%
For both the STD-D and the OD, CLint results are based on the better estimate derived by using either the MM model or an EXP model. Designs were considered to perform equally well, for a specific compound, if the relative difference in RMSE between the models was less than 10%.