Drug | Major SULT Specificitya | Predicted fuinc at 1.5 mg/mlb | Experimentally Derived fuinc (1.5 mg/ml HLC) | Unbound CLint,SULTc | |
---|---|---|---|---|---|
HLC | HIC | ||||
μl · min−1 · mg−1 | |||||
Quercetin | SULT1E1, SULT1A1 | 0.86 | N.D. | 141 ± 27 | 186 ± 20 |
Raloxifene | SULT1E1 | 0.03 | 0.14 | 45 ± 26 | 41 ± 8 |
Salbutamol | SULT1A3 | 0.84 | 0.59 | 8.7 ± 4.4 | 8.0 ± 3.3 |
Troglitazone | SULT1E1, SULT1A1 | 0.05 | 0.23 | 36 ± 14 | 57 ± 37 |
N.D., no experimental value could be determined because of compound degradation during equilibrium dialysis.
↵a References in supplemental data.
↵b Data predicted using Hallifax and Houston (2006) algorithm.
↵c Data represent the mean ± S.D. of three separate experiments using the same pool of HLC or HIC.