Pharmacodynamic parameters of repaglinide relating to the CYP2C8*3 genotype
Data are shown as mean (95% confidence interval).
| Genotype/Parameter | Insulin Concentration in Plasma | Blood Glucose Concentration | ||
|---|---|---|---|---|
| Mean Change | Maximal Change | Mean Change | Maximal Change | |
| mU/l | mM | |||
| All subjects (n = 29) | 5.5 (3.7 to 7.2) | 18.8 (12.6 to 25.0) | −0.53 (−0.71 to −0.34) | −1.69 (−1.97 to −1.41) |
| CYP2C8*1/*1 (n = 12) | 6.7 (3.4 to 10.1) | 23.9 (11.3 to 36.5) | −0.42 (−0.71 to −0.13) | −1.62 (−2.0 to −1.24) |
| CYP2C8*1/*3 (n = 13) | 5.2 (2.7 to 7.8) | 17.3 (9.1 to 25.6) | −0.65 (−0.97 to −0.30) | −1.83 (−2.37 to −1.28) |
| CYP2C8*3/*3 (n = 4) | 2.6 (−1.2 to 6.3) | 8.3 (−1.7 to 18.3) | −0.50 (−1.14 to −0.14) | −1.48 (−2.50 to −0.46) |
| p, one-way ANOVA | 0.293 | 0.240 | 0.563 | 0.658 |
| p, one-way ANOVA trend test (linear contrast) | 0.125 | 0.105 | 0.783 | 0.763 |