Change in dose-corrected concentration (C/D ratio) of four immunosuppressants between winter (January–March) and summer (July–September)
n refers to the total number of values included in the analysis (i.e., two per patient in the paired comparison).
| Unpaired Test | Paired Test | |||||
|---|---|---|---|---|---|---|
| n | Change in C/D Ratio | P Value | n | Change in C/D Ratio | P Value | |
| Tacrolimus | 2439 | −4.9% (−8.8; −0.9) | 0.02 | 1898 | −6.9% (−9.0; −4.9) | <0.0001 |
| Sirolimus | 366 | −17.2% (−25.3; −4.0) | 0.007 | 184 | −8.1% (−16.5; 0.3) | 0.06 |
| Cyclosporine | 2020 | 2.0% (−2.8; 4.4) | 0.67 | 1418 | 0.7% (−1.5; 2.9) | 0.52 |
| Mycophenolic acid | 397 | 1.2% (−12.4; 19.3) | 0.71 | 106 | −6.1% (−27.4; 14.5) | 0.55 |