Percentage of radioactive dose recovery in rats, monkeys, and humans after oral administration of [14C]brivanib alaninate
| Species | No. Subjects | Dose | Collection Interval | %Radioactive Dose | |||
|---|---|---|---|---|---|---|---|
| Urine | Bile | Feces | Totala | ||||
| h | |||||||
| Intact rat | 3 | 100 mg/kg | 0–168 | 9.46 ± 1.81 | N.A. | 83.58 ± 5.26 | 93.68 ± 6.17 |
| BDC rat | 3 | 100 mg/kg | 0–48 | 7.33 ± 1.51 | 78.35 ± 6.25 | 3.31 ± 0.31 | 88.99 ± 7.72 |
| Intact monkey | 3 | 10 mg/kg | 0–168 | 10.30 ± 0.39 | N.A. | 76.31 ± 5.77 | 89.79 ± 4.62 |
| BDC monkeyb | 2 | 10 mg/kg | 0–72 | 3.56 (2.95, 4.16) | 47.66 (41.95, 53.37) | 26.41 (20.45, 32.36) | 81.43 (71.87, 90.99) |
| Humanc | 4 | 800 mg | 0–288 | 12.18 ± 4.36 | N.A. | 81.54 ± 4.34 | 93.72 ± 1.08 |
N.A., not applicable.
↵a Recovery of radioactivity in cage wash and cage wipe was included in the total recovery for animal studies.
↵b Only two animals were dosed in the study. S.D. (CV) was not available.
↵c Radioactive dose recovery in human was reported in a separate manuscript and is included here for comparison (Mekhail et al., 2010).