Pharmacokinetic parameters for ELT (1 mg/kg) in rats with or without> RIF (20 mg/kg)
Each value represents the mean ± S.E.M. (n = 4).
↵* Significantly different from control (p < 0.05).
↵a Obtained in bile duct-cannulated rats.
↵b Calculated as the excretion rate of ELT into the bile for 6 to 8 h divided by the hepatic concentration at 8 h.
↵c Obtained for the liver in the integration plot analysis.