Pharmacokinetic data for NSAIDs and paracetamol
| Drug | Dosage | Cmax | Cmax | Cport vn | Referencea |
|---|---|---|---|---|---|
| mg | μg/ml | μM | |||
| Acetylsalicylic acid | 5001 | 3.61 | 20 | 205 | Acetylsalicylic acid (aspirin) product information, Bayer Vital GmbH (Leverkusen, Germany, 2009)1 |
| Diclofenac | 502 | 1.52 | 5 | 15 | Diclofenac (Voltaren) product information, Novartis Pharma GmbH (Nürnberg, Germany 2010)2 |
| Ibuprofen | 4003 | 393 | 187 | 316 | Ibuprofen (Urem forte) product information, Dr. Kade Pharmazeutische Fabrik GmbH (Berlin, Germany, 2010)3 |
| Lumiracoxib | 1004 | 2.44 | 8 | 31 | Mysler (2004)4 |
| Naproxen | 2 × 2505 | 875 | 379 | 524 | Zhou et al. (1998)5 |
| Paracetamol | 5006 | 96 | 60 | 280 | Paracetamol (Paracetamol-ratiopharm) product information, ratiopharm GmbH (Ulm, Germany, 2008)6 |
| Salicylic acidb | 500 (ASA)1 | 201 | 126 | 334 | |
ASA, acetylsalicylic acid; Cmax, maximal plasma concentration in the systemic circulation; Cport vn, predicted concentration in portal venous blood [according to Ito et al. (1998)].
↵a Superior numbers link data with reference.
↵b Calculated on the basis of a single 500-mg dose of acetylsalicylic acid.