Comparison of OATP1B1- and OATP1B3-mediated pravastatin uptake kinetics in the absence or presence of ibuprofen
Km and Vmax data are derived from data shown in Fig. 4.
| OATPB1 | OATP1B3 | |||
|---|---|---|---|---|
| Km | Vmax | Km | Vmax | |
| μM | pmol × mg protein−1 × min−1 | μM | pmol × mg protein−1 × min−1 | |
| Without ibuprofen | 104.0 | 36.3 | 228.0 | 62.8 |
| 30 μM ibuprofen | 59.7 | 82.3 | 182.7 | 74.7 |
| 250 μM ibuprofen | 86.8 | 221.2 | 67.8 | 124.8 |