Parameters | MHD/iv | MHD | (R)-MHD | (S)-MHD | MHD | (R)-MHD | (S)-MHD | MHD | (R)-MHD | (S)-MHD |
---|---|---|---|---|---|---|---|---|---|---|
150 mg | 200 mg | 250 mg | ||||||||
AUC(0–72 h) | μmol l−1 h | 109.2 | 55.7 | 69.0 | 142.4 | 59.1 | 92.2 | 280.1 | 131.7 | 191.7 |
Ae(0–72 h) | % of dose | 24.3 | N.D. | N.D. | 30.7 | N.D. | N.D. | 42.8 | N.D. | N.D. |
CL | l h−1 | 5.4 | 5.3 | 4.27 | 5.52 | 6.65 | 4.27 | 3.51 | 3.73 | 2.56 |
CLR | l h−1 | 1.31 | N.D. | N.D. | 1.7 | N.D. | N.D. | 1.5 | N.D. | N.D. |
iv, intravenous; N.D., not determined.