TABLE 2

Pharmacokinetic parameters for orally administered LVS (12.5 mg/kg) in IE-Cpr-null and WT mice pretreated with GFJ

Data from Fig. 1, E–F, were analyzed for the determination of pharmacokinetic parameters. Adult female mice (5–6 per group) were given a single dose of 4× strength GFJ through oral gavage, at 20 ml/kg, or were given water (vehicle control), followed 2 h later by a single oral dose of LVS, at 12.5 mg/kg. Values represent means ± S.D. (n = 5–6).

Strain	Pretreatment	T_max	C_max	t_1/2	AUC_{0–4 h}	CL/F
		min	μg/ml	min	min · μg/ml	ml/min
WT	Water	27 ± 7	0.2 ± 0.0	36 ± 5	10.9 ± 1.5	22.3 ± 2.7
WT	GFJ	34 ± 11	0.5 ± 0.1^{^a}	39 ± 13	34.4 ± 12.7^{^a}	8.1 ± 2.9^{^a}
IE-Cpr-null	Water	30 ± 0	0.4 ± 0.1	36 ± 9	30.0 ± 5.8	8.7 ± 1.7
IE-Cpr-null	GFJ	45 ± 17	0.4 ± 0.2	34 ± 12	34.2 ± 11.8	8.5 ± 4.2

CL/F, apparent clearance.
↵a P < 0.01, compared to the corresponding water-pretreated group (Student's t test).