TABLE 5

Main product ions obtained by performing MS/MS scans on the MH+ ions of odanacatib and its metabolites

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MetaboliteMH+ > MS/MS Fragmentsa
M-1508b > 299
M-2556 > 538, 518, 428, 313
M-3718 > 542, 460, 432, 313
M-4512 > 494, 492, 436, 385, 299, 177
M-5528 > 508, 452, 315, 177
M-6687 > 667, 611, 338
M-7540 > 520, 430, 313
M-8542 > 522, 504, 450, 432, 313
Odanacatib526 > 506, 450, 416, 313, 177

  • ↵a MS/MS spectra are available in the supplemental data.

  • ↵b 508 is not the MH+ ion, but (MH-H2O)+.