TABLE 6

Percentage of radioactive dose accounted for by metabolites in bile, feces, and urine after an intravenous dose (1 mg/kg) to bile duct-cannulated rats, dogs, and monkeys

MetaboliteRataDogbMonkeyc
M13.1 ± 0.8N.D.5.4
M20.1 ± 0.2N.D.Tr
M36.7 ± 1.1N.D.36
M422 ± 4.12.2Tr
M511 ± 3.05.5Tr
M64.6 ± 2.28.7Tr
M71.0 ± 0.5N.D.0.6
M811 ± 3.3N.D.32
Odanacatib19 ± 7.45.7<1

  • N.D., not detected; Tr, trace.

  • ↵a Data are the mean ± S.D. of n = 3.

  • ↵b Two animals were studied; bile data are from one animal, whereas only the 24- to 48-h fecal sample from both animals was profiled. Dog urine was not evaluated for metabolites.

  • ↵c Data are mean of n = 2.