Pharmacokinetic parameters of total radioactivity in rats and dogs after oral administration of [14C]GDC-0449
| Species and Sex | Dose | Cmax | tmax | t1/2 | AUC0–∞ |
|---|---|---|---|---|---|
| mg/kg | μg-Eq/g | h | μg-Eq · h/g | ||
| Rat | |||||
| Male (n = 3) | 50 | 40.0 | 1 | 45.2 | 400 |
| Female (n = 3) | 50 | 29.0 | 1 | 42.4 | 288 |
| Mean | 34.5 | 1 | 43.8 | 344 | |
| Dog | |||||
| Male (n = 2) | 5 | 3.44 | 3 | 36.8 | 169 |
| Female (n = 2) | 5 | 2.85 | 15 | 32.5 | 179 |
| Mean | 3.15 | 9 | 34.6 | 174 | |