TABLE 4

Major collision-induced product ions of GDC-0449 and its metabolites in rats and dogs

Analyte	[M + H]⁺ (m/z)	Major Fragment Ions (m/z)^{^a}
GDC-0449	421	342 (100), 313, 306, 217, 188, 155, 139
M1	437	419 (100), 340/342, 217, 139
M3	437	419, 401, 358 (100), 322, 247, 217, 204, 155, 139
M4	613	437 (100), 419, 340/342, 217
M5	613	437 (100), 419, 401, 358/360, 322, 204, 155
M6	613	595, 437 (100), 421, 401, 358
M7	726	709, 663, 597, 580, 494, 453(100), 374, 217, 155, 139
M8	726	709, 663, 597, 580, 494, 453 (100), 217, 199, 155, 139
M9	443	426 (100), 398, 380, 217, 155
M10	437	401, 409, 383 (100), 323, 217, 139
M11	437	419, 409 (100), 383, 374, 339, 304, 229, 217, 204, 168, 155
M12	437	419, 401, 383 (100), 358, 323, 217, 155
M13	444	426 (100), 398, 380, 362, 301, 217, 155
M14	437	419, 401, 383 (100), 391, 217, 155
M15	453	435 (100), 417, 356, 338, 328, 217, 155
M16	599	437 (100), 419, 401, 340, 217, 155
M17	517	437, 419, 358 (100), 322, 217, 204, 155, 139
M18	471	453, 443, 426, 425, 397

↵a Base peak is labeled as 100 in parentheses.