Detection of vismodegib and metabolites in pooled urine and feces after oral administration of [14C]vismodegib to human subjects
| Analyte | Percentage of Dose | |||
|---|---|---|---|---|
| Urine | Feces | |||
| 0–312 h | 0–72 h | 72–312 h | 0–312 h | |
| Vismodegib | D | 21.7 | 9.0 | 30.7 |
| M1 | D | D | 1.1 | 1.1 |
| M3 | D | 3.2 | 12.0 | 15.2 |
| M4 | D | ND | ND | ND |
| M5 | D | ND | ND | ND |
| M13 | D | D | 3.0 | 3.0 |
| M14 | D | ND | D | D |
| M18 | D | D | 2.0 | 2.0 |
D, detected by MS only; ND, not detected by MS.