Analytical conditions for measuring inhibitor depletion by LC/MS/MS
Ionization mode indicates the type of ionization (i.e., ESI) and the polarity (+ or −).
| Inhibitor | Ionization Mode | Mass Transition Monitored | Internal Standard |
|---|---|---|---|
| amu | |||
| Ticlopidine | ESI+ | 264 → 154 | Dextromethorphan |
| Tienilic acid | ESI− | 329 → 274 | Probenecid |
| S-Fluoxetine | ESI+ | 310 → 44 | Probenecid |
| Paroxetine | ESI+ | 330 → 192 | Dextromethorphan |
| Azamulin | ESI+ | 479 → 175 | d6-Dehydronifedipine |
| Mibefradil | ESI+ | 496 → 202 | d5-N-Desalkylebsatine |
amu, atomic mass units; ESI, electrospray ionization.