TABLE 1

Values of pharmacokinetic parameters identified in study

Treatment Subject	Plasma Vismodegib			Plasma Total Radioactivity			AUC_0-inf Ratio^{^a}
Treatment Subject	C_max	AUC_0-inf	t_1/2	C_max	AUC_0-inf	t_1/2	AUC_0-inf Ratio^{^a}
	μM	μM · h	h	μM-equiv	μM-equiv · h	h
S0007	8.12	1940	157	8.81	2210	190	0.878
S0008	9.49	4180	269	11.5	4230	278	0.988
S0009	7.31	4510	329	13.1	7080	291	0.637
S0010	6.08	2540	277	7.00	2830	262	0.898
S0011	7.56	2040	182	12.1	3040	194	0.671
S0012	7.50	1550	128	16.9	3310	149	0.468
Mean	7.67	2790	224	11.6	3780	227	0.757
S.D.	1.12	1250	79.2	3.47	1750	57.5	0.197

↵a AUC_0-inf ratio is equal to plasma vismodegib AUC_0-inf/plasma total radioactivity AUC_0-inf.