Prediction of Vdss of PF-02413873 in rat, dog, and human using tissue composition equations
| Species | Plasma Volume of Distribution at Steady State (l/kg) | ||
|---|---|---|---|
| Measured | Rodgers and Rowland (2006) | Single Species Scaling | |
| Rat | 5.1 | 3.5 | |
| Dog | 2.5 | 2.8 | |
| Human | 2.6 | 3.5 (rat) 2.9 (dog) | |