Characteristics of control and CRF rats
Data are the mean ± S.D. Measurements were made at the time of sacrifice. Urinary collection was begun the day before. Blood urea, creatinine, and urine creatinine were determined with an Architect C1600 clinical analyzer (Abbott Laboratories).
| Control (n = 20) | CRF (n = 20) | p Value | |
|---|---|---|---|
| Body weight (g) | 342.7 ± 30.9 | 327.4 ± 55.1 | 0.29 |
| Serum creatinine (μmol/l) | 62.5 ± 4.0 | 229.5 ± 86.2 | p < 0.001 |
| Creatinine clearance (μl/100 g of b.wt./min) | 313.1 ± 49.9 | 63.7 ± 35.4 | p < 0.001 |
| Serum urea (mmol/l) | 4.5 ± 1.0 | 38.2 ± 19.0 | p < 0.001 |