Pharmacokinetic parameters of PF-02413873 in rat after intravenous bolus and oral solution administration
Data are mean ± S.D. (n = 3).
| Parameter | Intravenous | Oral |
|---|---|---|
| n | 3 | 3 |
| Dose (mg/kg) | 0.4 | 0.4 |
| CLp (ml · min−1 · kg−1) | 84 ± 21 | |
| Vdss (l/kg) | 5.3 ± 1.5 | |
| t1/2 (h) | 1.1 ± 0.1 | |
| MRT (h) | 2.4 ± 0.6 | |
| AUCinf (ng · h−1 · ml−1) | 83 ± 24 | 0 |
| F (%) | 0 |
CLp, plasma clearance; AUCinf, area under plasma concentration vs. time profile from time 0 extrapolated to infinite time; t1/2, terminal half-life; Vdss, volume of distribution at steady state; MRT, mean residence time; F, oral bioavailability.