Percentage of total radioactivity represented by vismodegib, M3, and other metabolites in pooled feces samples collected over 24-h intervals
| Collection Period | Percentage Total 14C | ||
|---|---|---|---|
| Vismodegib | M3 | Othera | |
| h | |||
| 0–24 | 117 | 0.638 | |
| 24–48 | 92.3 | 3.52 | 4.18 |
| 48–72 | 82.1 | 5.13 | 12.8 |
| 72–96 | 67.7 | 8.40 | 23.9 |
| 96–120 | 37.7 | 10.7 | 51.6 |
| 120–144 | 13.2 | 21.3 | 65.5 |
| 144–168 | 12.8 | 7.28 | 79.9 |
| 168–192 | 14.0 | 6.82 | 79.1 |
| 192–216 | 10.6 | 8.83 | 80.6 |
| 216–240 | 22.0 | 8.39 | 69.6 |
| 240–264 | 10.9 | 5.82 | 83.3 |
| 264–288 | 18.0 | 6.41 | 75.6 |
| 288–312 | 13.9 | 13.4 | 72.7 |
↵a Vismodegib and M3 were measured over each 24-h interval, whereas “Other” was calculated by subtracting the sum of vismodegib and M3 from total 14C.