TABLE 3 Experimentally determined IC50 values based on the initial or final inhibitor concentration and the ratio of IC50 values determined with dilution (10–40-fold) versus no dilution for fluconazole, a direct-acting inhibitor of CYP3A4, and methimazole and diltiazem, metabolism-dependent inhibitors of CYP3A4 based on midazolam 1′-hydroxylation (4 μM)
All values were rounded to two significant figures. [HLM] indicates microsomal protein concentration before and after dilution. [Initial] refers to initial or predilution concentrations of inhibitor; [Final] refers to final or postdilution concentrations.