TABLE 2

Excretion of radioactivity in human urine and feces after a single oral dose of [¹⁴C]eltrombopag olamine

Collection Interval	%Administered Dose in Subject
Collection Interval	1	2	3	4	5	6	Mean	S.D.
Urine
0–12 h	3.25	8.46	4.89	2.86	2.87	2.38	4.12	2.30
12–24 h	4.51	13.8	8.08	5.97	5.69	8.37	7.74	3.32
24–48 h	7.63	12.8	10.7	9.56	7.81	15.6	10.7	3.08
48–72 h	3.83	4.22	5.05	3.65	3.47	3.44	3.94	0.61
72–96 h	2.09	2.63	2.07	1.60	1.63	1.76	1.96	0.39
96–120 h	1.38	1.70	1.20	1.29	0.85	0.46	1.15	0.43
120–144 h	0.73	1.00	0.43	0.65	0.52	0.36	0.62	0.23
144–168 h	0.44	0.78	0.44	0.41	0.53	0.25	0.48	0.18
Subtotal	23.9	45.4	32.9	26.0	23.4	32.6	30.7	8.32
Feces
0–12 h	N.S.	N.S.	N.S.	N.S.	N.S.	N.S.	0.00	0.00
12–24 h	0.06	N.S.	0.04	N.S.	0.02	N.S.	0.02	0.03
24–48 h	N.S.	N.S.	6.12	N.S.	15.9	34.9	9.49	13.9
48–72 h	21.3	21.0	12.4	22.8	12.0	N.S.	14.9	8.69
72–96 h	N.S.	N.S.	17.3	27.8	24.2	N.S.	11.6	13.1
96–120 h	28.8	N.S.	14.0	N.S.	9.58	23.9	12.7	12.0
120–144 h	9.75	19.9	9.12	11.0	6.13	N.S.	9.32	6.51
144–168 h	N.S.	N.S.	0.55	2.78	1.95	N.S.	0.88	1.20
Subtotal	59.9	40.9	59.5	64.4	69.8	58.8	58.9	9.74
Total^{^a}	83.8	86.3	92.4	90.4	93.2	91.5	89.6	3.73

N.S., no sample obtained, considered zero for calculation of mean and S.D.
a The total recovery included the radioactivity recovered from toilet tissues (<0.1% of dose per subject).