Individual percentages of eltrombopag-related materials in human excreta after a single oral administration of 75 mg of [14C]eltrombopag
| Metabolite | %Administered Dose in Subject | ||||||
|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | Mean ± S.D. | |
| Urine | |||||||
| M3 | N.C. | N.C. | N.C. | N.C. | N.C. | N.C. | N.A. |
| M4 | 14.2 | 32.9 | 19.7 | 17.2 | 15.8 | 21.8 | 20.3 ± 6.8 |
| Unknown 1 | N.D. | N.D. | 4.5 | N.D. | N.D. | N.D. | N.A.a |
| Total quantified | 14.2 | 32.9 | 24.2 | 17.2 | 15.8 | 21.8 | 21.1 ± 6.8 |
| Total radioactivity | 23.9 | 45.4 | 32.9 | 26.0 | 23.4 | 32.6 | 30.7 ± 8.3 |
| Feces | |||||||
| M5, M6, and M7 | 26.1 | 4.4 | 12.1 | 36.7 | 32.0 | 12.4 | 20.6 ± 12.8 |
| Eltrombopag | 17.9 | 15.5 | 25.9 | 15.4 | 23.1 | 23.0 | 20.1 ± 4.5 |
| Unknown 2 | N.D. | 6.6 | 6.1 | N.D. | N.D. | 8.8 | 3.6 ± 4.0 |
| Total quantified | 44.0 | 26.5 | 44.1 | 52.1 | 58.1 | 44.2 | 44.3 ± 9.9 |
| Total radioactivity | 59.9 | 40.9 | 59.5 | 64.4 | 69.8 | 58.8 | 58.9 ± 9.7 |
N.C., not calculated because M3 is a cleavage product that does not retain the 14C label after the cleavage; thus, quantitation via radioprofiling is not possible; N.D., not detected; N.A., not applicable.
a The mean value was not calculated because this metabolite was detected in one subject only.