TABLE 6

Summary of the average, range, and CV of F_G values predicted from individual clearance data determined in eight human jejunal microsomal preparations using the PBPK modeling approach

	F_G	Range	CV
			%
Atorvastatin	0.83	0.73–0.90	8
Buspirone	0.65	0.48–0.85	24
Cyclosporine	0.84	0.71–0.94	11
Felodipine	0.11	0.06–0.17	42
Indinavir^{^a}	0.94	0.92–0.98	3
Lovastatin	0.08	0.03–0.16	59
Midazolam	0.33	0.19–0.52	36
Nisoldipine	0.04	0.02–0.07	53
Saquinavir^{^a}	0.36	0.19–0.55	39
Simvastatin	0.03	0.02–0.06	45
Tacrolimus^{^a}	0.08	0.03–0.15	58
Terfenadine^{^a}	0.12	0.03–0.23	65

a Based on apparent permeability (apical-basolateral) data in the presence of a P-glycoprotein inhibitor.