Binding in the Presence of NADPH | ||||
---|---|---|---|---|
Rat | Human | |||
pmol/mg | ||||
Incubation time (min) | 30 | 60 | 30 | 60 |
GSK977779 (M) | 72.2 | 177 | 86.3 | 136 |
Acetaminophena control (M) | N.A. | 75.8 | N.A. | 104 |
GSK977779 (F) | 140 | 295 | 83.9 | 132 |
Acetaminophena control (F) | N.A. | 22.5 | N.A. | 158 |
M, male; F, female; N.A., not applicable.
a Acetaminophen control incubations were performed for 60 min only.