Inhibitor (mg/day) | AUCI/AUC | Referencesa | |||||
---|---|---|---|---|---|---|---|
CER | FLV | MTK | PIO | REP | ROS | ||
Cimetidine (1000–1200 mg) | 1.0 | 1.2 | Mück et al., 1997; Hatorp and Thomsen, 2000 | ||||
Gemfibrozil (1200 mg)a | 5.6 | 1.1 | 4.5 | 3.3 | 7.7 | 2.3 | Spence et al., 1995; Backman et al., 2002; Niemi et al., 2003a,b, 2004a; Deng et al., 2005; Jaakkola et al., 2005; Tornio et al., 2008b; Karonen et al., 2010 |
Itraconazole (100–200 mg) | 1.3 | 0.9 | 1.1 | 1.4 | Kivistö et al., 1998; Mazzu et al., 2000; Niemi et al., 2003b; Jaakkola et al., 2005 | ||
Montelukast (10 mg) | 1.0 | 1.0 | 1.0 | Jaakkola et al., 2006; Kajosaari et al., 2006; Kim et al., 2007 | |||
Telithromycin (800 mg) | 1.0 | 1.8 | Kajosaari et al., 2006 | ||||
Trimethoprim (320–400 mg) | 1.4 | 1.6 | 1.4 | Niemi et al., 2004a,b; Hruska et al., 2005; Tornio et al., 2008a |
CER, cerivastatin; FLV, fluvastatin; MTK, montelukast; PIO, pioglitazone; REP, repaglinide; ROS, rosiglitazone.
a Gemfibrozil glucuronide is a time-dependent inactivator of CYP2C8.