TABLE 10

Selected mass spectra data for GSK977779 and its metabolites

Metabolite	m/z
Metabolite	[M + H]⁺	Significant MS² and MS³ Product Ions^{^a}
GSK977779	444	MS²: 365, 322, 297, 255, 243, 202, 187, 170, 106
M1	357	MS²: 322, 280, 268, 198, 187, 156, 144
M2	357	MS²: 322, 280, 268, 198, 187, 156, 144
M4	341	MS²: 324, 268, 243, 200, 187, 170, 144, 99
M5	620	MS²: 603, 444, 427
M9	388	MS²: 266, 202, 199, 187, 170
M10	636	MS²: 460, 444; MS³ on 460: 443, 313^{^b}
M11	460	MS²: 442, 400, 388, 295, 253, 245, 241, 202, 199, 187
M12	460	MS²: 442, 400, 388, 295, 253, 245, 241, 202, 199, 187
M14	343	MS²: 297, 255, 243, 199, 187, 170
M17	476	MS²: 458; MS³ on 458: 440, 386, 311, 241, 200, 187^{^b}
M19	474	MS²: 456, 428, 309, 245, 212, 202
M21	460	MS²: 442, 313, 295, 255, 243, 200, 187
M22	460	MS²: 443, 313, 271, 259, 203, 202, 188, 106
M23	470	MS²: 425, 324, 130
M24	460	MS²: 442, 388, 295, 241, 202, 187
M25	355	MS²: 337; MS³ on 337: 320, 243, 187, 169, 95^{^c}
M26	355	MS²: 337; MS³ on 337: 320, 243, 187, 169, 95^{^c}
M27	636	MS²: 460, 442, 202
M28	476	No MSⁿ data
M29	731	MS²: 713, 585, 458, 274, 199, 145
M30	731	MS²: 713, 585, 458, 274, 199, 145
M31	315	MS²: 297; MS³ on 297: 255, 243, 24^{^b}
M32	329	MS²: 311; MS³ on 311: 283, 255, 243, 227, 199, 187, 169^{^c}
M33	426	MS²: 304, 279, 248, 237, 225, 202, 169, 123, 106
M34	341	MS²: 323, 295, 281, 243, 239, 225, 187
M35	442	MS²: 414, 320, 295, 239, 200, 106

a Major or significant positive product ions. Unless otherwise noted, reported MS fragments were acquired on a Waters QToF II.
b MSⁿ data from Thermo Fisher LTQ.
c Species exhibited significant in-source fragmentation. The dominant in-source fragment ion (−H₂O) is labeled MS² and was used to generate additional fragments (MS³).