%Sample Radioactivity | ||||
---|---|---|---|---|
Pooled HLM | HLM (UGT1A1*28/*28) | UGT2B4 | UGT2B7 | |
M6a | 15.6 | 19.6 | 1.4 | MSb |
BMS-690514 | 84.4 | 79.6 | 98.0 | ∼100 |
a Metabolite M6 was not detected by either radioactivity or mass spectrometry in incubations with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT2B15, or UGT2B17.
b Metabolite M6 was detected by mass spectrometry (MS) but not by radioactivity in incubations with UGT2B7.