TABLE 3

CL_{int, u} of gemfibrozil, mycophenolic acid, raloxifene, and biochanin A metabolism by rat liver and intestinal microsomes

Microsomal incubations were fortified with UDPGA or NADPH. CL_{int, u} values represent the mean ± S.D. of three determinations.

Compounds	CL_{int, u}
	UGT		P450
	Liver	Intestine	Liver	Intestine
	ml · min⁻¹ · mg protein⁻¹
Gemfibrozil	0.273 ± 0.008	0.001 ± 0.002	0.025 ± 0.008	0.002 ± 0.002
Mycophenolic acid	0.042 ± 0.006	0.229 ± 0.014	0.006 ± 0.003	0.002 ± 0.001
Raloxifene	0.359 ± 0.038	0.992 ± 0.099	0.293 ± 0.096	0.019 ± 0.007
Biochanin A	5.050 ± 0.744	2.845 ± 0.234	0.062 ± 0.004	0.004 ± 0.004