Pharmacokinetic variables for Dein, Gein, and their metabolites in 10 subjects
| tmax | Cmax | AUC | ||||
|---|---|---|---|---|---|---|
| Mean ± S.D. | RSD | Mean ± S.D. | RSD | Mean ± S.D. | RSD | |
| h | % | μmol/l | % | μmol · h/l | % | |
| Dein | 2.3 ± 1.5 | 65.5 | 0.01 ± 0.02 | 115.8 | 0.08 ± 0.25 | 310.3 |
| D-4′,7-diG | 2.9 ± 1.5 | 52.5 | 0.05 ± 0.02 | 39.6 | 0.95 ± 0.25 | 26.7 |
| D-4′,7-diS | ||||||
| D-7G-4′S | 7.4 ± 1.9 | 25.6 | 0.34 ± 0.94 | 275.3 | 6.24 ± 1.26 | 20.2 |
| D-7-G | 6.1 ± 2.6 | 42.6 | 0.09 ± 0.04 | 46.2 | 1.72 ± 1.22 | 70.8 |
| D-4′-G | 4.5 ± 2.5 | 54.7 | 0.10 ± 0.07 | 72.6 | 1.63 ± 1.70 | 104.2 |
| D-7-S | 1.6 ± 1.3 | 79.1 | 0.09 ± 0.03 | 32.0 | 0.68 ± 0.42 | 61.5 |
| D-4′-S | 4.1 ± 3.1 | 75.8 | 0.04 ± 0.01 | 38.2 | 0.41 ± 0.34 | 83.5 |
| Total | 4.7 ± 2.5 | 53.2 | 0.64 ± 0.18 | 28.2 | 11.70 ± 4.38 | 37.4 |
| Gein | 8.0 ± 8.9 | 111.8 | 0.01 ± 0.01 | 79.2 | 0.23 ± 0.46 | 200.7 |
| G-4′,7-diG | 6.8 ± 3.0 | 44.3 | 0.45 ± 0.26 | 57.8 | 8.25 ± 4.36 | 52.8 |
| G-4′,7-diS | ||||||
| G-7G-4′S | 6.4 ± 2.5 | 38.4 | 0.85 ± 0.39 | 46.2 | 16.78 ± 8.03 | 47.8 |
| G-7-G | 5.0 ± 1.7 | 34.0 | 0.11 ± 0.04 | 39.9 | 1.85 ± 1.03 | 55.6 |
| G-4′-G | 3.9 ± 2.4 | 61.0 | 0.14 ± 0.07 | 50.0 | 1.87 ± 1.58 | 84.3 |
| G-7-S | 1.7 ± 1.3 | 73.6 | 0.18 ± 0.11 | 60.5 | 1.58 ± 1.00 | 63.4 |
| G-4′-S | 17.1 ± 16.0 | 93.4 | 0.02 ± 0.12 | 522.3 | 0.49 ± 0.53 | 108.6 |
| Total | 5.4 ± 2.1 | 38.9 | 1.58 ± 0.55 | 34.8 | 31.05 ± 10.46 | 33.7 |