TABLE 4

Distribution of radioactive metabolites in urine after oral dosing [¹⁴C]ticagrelor in mice, rats, and marmosets

Metabolites	Percentage of Administered Dose
	Mice		Rats		Marmosets
	Male	Female	Male	Female	Male	Female
	0–48 h				0–120 h
Ticagrelor	ND	ND	ND	ND	NQ	0.1
M1	1.38	0.04	0.3	0.6	0.8	0.7
M2	0.95	0.01	0.4	0.3	0.04	0.2
M3a	ND	ND	ND	ND	0.1	0.1
M4a	ND	ND	ND	ND	0.4	0.5
M5 (AR-C133913)	0.48	0.03	1.2	1.6	3.9	2.8
M7a	ND	ND	0.23	0.04	NQ	0.08
M7b	ND	ND	0.08	0.01	NQ	NQ
M7d	ND	ND	ND	ND	NQ	0.02
M10a	ND	ND	0.09	0.08	NQ	NQ
M10b	ND	ND	0.25	0.25	NQ	0.1
M8 (AR-C124910)	ND	ND	ND	ND	NQ	NQ
M11	0.68	0.04	0.4	0.7	0.1	0.2
M12	0.30	0.02	0.4	0.4	1.3	1.1
M13	ND	ND	ND	ND	NQ	0.04
Others^{^a}	0.73	0.07	1.2	0.5	0.5	0.8

ND, not detected; NQ, detected by LC-MS/MS only, not quantifiable by radiodetector.
a Sum of total uncharacterized radioactivity.