Administration and urinary elimination of drug-related materials after oral administration of [14C]eltrombopag to female mice with or without antibiotic treatment
| Group (n = 4) | Antibiotic Treatmenta | [14C]Eltrombopag Administered | %Administered Dose Eliminated in Urineb |
|---|---|---|---|
| mg/kg | |||
| 1 | 1200 | 10 | 1 |
| 2 | 1200 | 0 | N.A. |
| 3 | 0 | 10 | 5 |
| 4 | 0 | 0 | N.A. |
N.A., not available.
a Total daily dose of antibiotics; mice were dosed twice daily (on days 1–4 and once on day 5) with a mixture of bacitracin, neomycin, and streptomycin at 200 mg/kg each.
b Data are mean values.