Distribution of radioactive metabolites in pooled plasma in mice, rats, and marmosets after oral administration of [14C]ticagrelor
| Metabolites | Percentage of Total Radioactivity in the Sample | |||||
|---|---|---|---|---|---|---|
| Micea | Rats | Marmosets | ||||
| Male | Female | Male | Female | Male | Female | |
| 2 h | 4 h | 0.5–8 h | ||||
| Ticagrelor | 38 | 45 | 63 | 75 | 43 | 41 |
| M4a | NA | NA | ND | ND | 2.5 | 2.3 |
| M5 (AR-C133913) | 6.8 | 4.5 | 1.6 | 3.2 | 7.8 | 16 |
| M9a | NA | NA | ND | ND | 6.7 | 4.1 |
| M8 (AR-C124910) | 35 | 35 | 22 | 12 | 13 | 13 |
| M10a | NA | NA | 0.2 | 0.4 | ND | ND |
| M12 | NA | NA | ND | ND | 1.5 | 1.0 |
| Othersb | 20 | 35 | 13 | 9.4 | 26 | 23 |
NA, not available; ND, not detected.
a Only metabolite profiling was conducted in mice plasma samples with comparison of reference standards.
b Sum of total uncharacterized radioactivity.