Extractable and nonextractable (bound) radioactivity in plasma samples after single oral administration of [14C]GSK977779 (30 mg/kg) to male and female rats
| Time Postdose | Sex | Total Drug-Related Materiala | %Extractableb | %Boundc | Boundd | %Total Recoverye |
|---|---|---|---|---|---|---|
| h | μg eq/g | pmol/mg protein | ||||
| 2 | M | 211 | 87.3 | 1.2 | 83.5 | 88.5 |
| 4 | M | 157 | 87.0 | 2.9 | 150 | 89.9 |
| 8 | M | 84 | 75.2 | 7.0 | 195 | 82.2 |
| 24 | M | 14 | 56.5 | 24.8 | 116 | 81.3 |
| 2 | F | 226 | 67.0 | 18.3 | 1366 | 85.3 |
| 4 | F | 149 | 40.7 | 43.3 | 2145 | 84.0 |
| 8 | F | 90 | 17.0 | 75.3 | 2228 | 92.3 |
| 24 | F | 44 | 6.3 | 81.9 | 1182 | 88.2 |
M, male; F, female.
a Mean concentration of radioactivity (n = 3) in plasma of males and females. All other data were obtained from pooled samples per sex across time points.
b Percentage of total radioactivity recovered after solvent extraction.
c Percentage of total radioactivity recovered after solubilization of the plasma protein pellets.
d Bound radioactivity expressed as picomole equivalent of GSK977779 per milligram of plasma protein.
e The sum of the percentage extractable and the percentage nonextractable.