In vitro human FcRn binding and dissociation parameters of MK-1 to MK-6
| Compounds | MK-1 | MK-2 | MK-3 | MK-4 | MK-5 | MK-6 |
|---|---|---|---|---|---|---|
| Isotype | IgG1 | IgG2 | IgG1 | IgG2 | IgG1 | IgG2 |
| Faba | A | A | B | B | C | C' |
| KD (nM) at pH 6.0 | 56.3 | 73.0 | 18.5 | 24.7 | 25.7 | 33.2 |
| %bound at pH 7.3 (%) | 0.4 | 0.0 | 2.5 | 2.9 | 12.9 | 9.9 |
a MK-1 and MK-2 have an identical Fab domain A, MK-3 and MK-4 have an identical Fab domain B, and MK-5 and MK-6 have closely related, but slightly different, Fab domains C and C′.