Key pharmacokinetic parameters of eltrombopag after oral administration of eltrombopag olamine at 10 mg/kg to female mice without or with antibiotic treatment
Data are mean ± S.D., where applicable.
| Group | Treatment | AUC0–ta | Cmax | Tmax |
|---|---|---|---|---|
| μg · h/ml | μg/ml | h | ||
| A | Naive mice with eltrombopag | 93.9 ± 24.4 | 21.5 ± 4.3 | 1.01 |
| B | Antibiotic-treated mice with eltrombopag | 70.3 ± 11.8 | 19.3 ± 2.2 | 1.04 |
| C | Vehicle-treated mice with eltrombopag | 109 ± 15.8 | 21.2 ± 5.8 | 1.02 |
a AUC0–t refers to the area from time 0 to the last quantifiable concentration.