Time Postdose | Sex | Total Drug-Related Materiala | %Extractableb | %Boundc | Boundd | %Total Recovery |
---|---|---|---|---|---|---|
h | μg eq/g | pmol/mg protein | ||||
2 | M | 84.8 | 97.1 | N.A. | N.A. | N.A. |
4 | M | 67.4 | 98.1 | N.A. | N.A. | N.A. |
8 | M | 32.4 | 97.5 | N.A. | N.A. | N.A. |
24 | M | 6.8 | 90.7 | N.A. | N.A. | N.A. |
2 | F | 89.2 | 97.4 | N.A. | N.A. | N.A. |
4 | F | 64.0 | 95.5 | N.A. | N.A. | N.A. |
8 | F | 25.8 | 88.5 | N.A. | N.A. | N.A. |
24 | F | 8.9 | 85.1 | 14.9 | 18.4 | 100 |
M, male; F, female; N.A., not applicable.
a Mean concentration of radioactivity (n = 3) in liver of males and females. Extraction data were obtained from pooled samples per sex across time points.
b Percentage of total radioactivity recovered after solvent extraction.
c Calculated percentage of total nonextractable (bound) radioactivity assuming a sum of extractable plus nonextractable radioactivity equal to 100% for the female 24-h liver sample. No experimental determination of the bound radioactivity was done for any of the liver samples.
d Bound radioactivity expressed as picomole equivalent of GSK977779 per milligram of liver protein.