Effect of amitriptyline, nortriptyline, itraconazole, phenytoin, S-naproxen, and lamotrigine on ANS fluorescence in the presence of HLMs (0.25 mg/ml)
Data are shown as means of duplicate measurements (<5% variance).
| Drug | Percentage ANS Fluorescence Increment/Decrement | ||
|---|---|---|---|
| 100 μM | 200 μM | 500 μM | |
| Itraconazole | 138 | 239 | 548 |
| Amitriptyline | 43 | 66 | 139 |
| Nortriptyline | 40 | 64 | 122 |
| Phenytoin | −8 | −13 | −21 |
| S-Naproxen | 3 | −3 | −8 |
| Lamotrigine | 4 | 6 | 6 |