Summary of plasma eltrombopag and plasma and blood total radioactivity PK parameters
n = 6. Data are presented as geometric mean (range) [% coefficient of variation or %CV], except for Tmax, which is presented as median (minimum, maximum).
| Analyte | Matrix | AUC0–∞ | Cmax | Tmax | t1/2 |
|---|---|---|---|---|---|
| μg · h/ml | μg/ml | h | h | ||
| Eltrombopag | Plasma | 145 (101–208) [35.5] | 10.9 (8.68–13.6) [21.5] | 2.50 (2.00, 4.02) | 32.3 (26.7–39.1) [18.3] |
| Radioactivity | Plasma | 240 (163–354) [38] | 10.0 (7.70–13.0) [25.5] | 2.50 (1.50, 4.00) | 49.3 (36.7–66.2) [28.7] |
| Radioactivity | Whole blood | 135 (93.0–196) [36.8] | 5.29 (3.99–7.01) [27.4] | 2.50 (2.00, 4.00) | 51.9 (34.3–78.5) [41.0] |