Quantification of radiolabeled metabolites in plasma after single oral administration of [14C]GSK977779 at 30 mg/kg to male and female rats
| Parent or Metabolite | Percentage of Total Radioactivity Recovered in Extracta | |||||||
|---|---|---|---|---|---|---|---|---|
| Intact Male | Intact Female | |||||||
| 2 h | 4 h | 8 h | 24 h | 2 h | 4 h | 8 h | 24 h | |
| P | 98.7 | 55.7 | 55.2 | 94.8 | 85.7 | 68.6 | 93.5 | 6.36 |
| M4 | ND | 2.24 | 1.48 | 0.26 | 0.84 | 2.83 | 0.57 | 1.15 |
| M11 | ND | 3.24 | 3.20 | ND | 0.50 | 1.79 | 0.38 | NQ |
| M12 | ND | 12.1 | 13.2 | ND | ND | 2.46 | 0.19 | 1.15 |
| M14 | ND | 10.5 | 10.8 | 0.80 | 1.73 | 7.23 | 2.67 | 4.05 |
| M21 | 1.26 | 8.85 | 8.80 | 2.40 | 11.2 | 15.8 | 1.91 | 1.73 |
| M23 | ND | ND | ND | ND | ND | ND | ND | 49.7 |
| M35 | ND | 7.34 | 7.30 | 1.72 | ND | 1.25 | 0.76 | 24.3 |
P, parent compound; ND, not detected; NQ, detected by mass spectrometry but not quantifiable by radio-HPLC.
a Percentage distribution of radioactivity under each identified peak.