Distribution of radioactive metabolites in feces after oral dosing [14C]ticagrelor in mice, rats, and marmosets
| Metabolites | Percentage of Administered Dose | |||||
|---|---|---|---|---|---|---|
| Mice | Rats | Marmosets | ||||
| Male | Female | Male | Female | Male | Female | |
| 0–24 h | 0–48 h | |||||
| Ticagrelor | 32.9 | 33.5 | 34.5 | 47.9 | 23.6 | 29.5 |
| M1 | ND | ND | ND | ND | 0.4 | ND |
| M4a | ND | ND | ND | ND | 0.1 | ND |
| M5 (AR-C133913) | 13.9 | 4.02 | 5.6 | 6.1 | 3.1 | 2.8 |
| M7a | 8.46 | 15.1 | 0.8 | 1.1 | 0.8 | 0.6 |
| M7b | ND | ND | 0.6 | 0.3 | 0.6 | 0.3 |
| M7c | 4.09 | 6.85 | 0.5 | ND | NQ | NQ |
| M7d | ND | ND | 3.6 | 2.4 | 2.7 | 1.8 |
| M7e | ND | ND | 2.1 | 1.9 | 1.4 | 0.8 |
| M8 (AR-C124910) | 27.7 | 29.5 | 4.9 | 6.0 | 2.8 | 3.8 |
| M9a | ND | ND | 0.7 | 0.2 | NQ | 0.1 |
| M10a | * | * | 1.1 | 1.5 | 1.1 | 0.8 |
| M10b | 7.25 | 5.53 | 2.1 | 2.1 | 0.9 | 1.4 |
| M10c | ND | ND | ND | ND | 0.2 | ND |
| M10d | ND | ND | 0.7 | ND | 0.2 | 0.2 |
| M12 | * | * | 0.6 | 1.1 | 1.0 | 1.0 |
| M13 | ND | ND | 6.9 | 8.5 | 4.8 | 4.3 |
| Othersa | 1.28 | 0.40 | 9.0 | 2.7 | 4.8 | 3.7 |
ND, not detected; NQ, detected by LC/MS only, not quantifiable by radiodetector.
* M12 coeluted with M5; M7a coeluted with M10a in mice samples.
a Sum of total uncharacterized radioactivity.