Analyte | Time | Mean ± S.D. | |
---|---|---|---|
Percentage (%) of Dose (Urine) | Percentage (%) of Dose (Bile) | ||
h | |||
Carfilzomib | 0–4 | 0.032 ± 0.021 | 0.017 ± 0.019 |
4–8 | 0.005 ± 0.007 | BQL | |
8–24 | 0.003 ± 0.004 | NA | |
M14 | 0–4 | 18.6 ± 10.6 | 12.9 ± 2.3 |
4–8 | 3.86 ± 2.75 | 0.230 ± 0.108 | |
8–24 | 3.29 ± 1.29 | NA | |
M15 | 0–4 | 0.164 ± 0.127 | 14.7 ± 2.1 |
4–8 | 0.027 ± 0.034 | 0.076 ± 0.056 | |
8–24 | 0.045 ± 0.006 | NA | |
M16 | 0–4 | 0.127 ± 0.100 | 2.64 ± 3.09 |
4–8 | 0.027 ± 0.045 | 0.013 ± 0.010 | |
8–24 | 0.010 ± 0.006 | NA | |
Total | 0–24 | 26 ± 12 | 31 ± 5 |
NA, not applicable (bile samples were not collected from 8 to 24 h); BQL, below the quantitation limit.