Compound | Vss | Predicted Vss | |||
---|---|---|---|---|---|
Scenario 1 | Scenario 2 | Scenario 3 | Scenario 4 | ||
l/kg | l/kg | ||||
Amlodipine | 17 | 8.1 | 3.4 | 3.3 | 31.9 |
Propranolol | 3.1 | 1.3 | 2.8 | 2.3 | 4.0 |
UK-390957 | 5.2a | 25.5b | 2.9 | 1.6 | 3.9 |
AAFE | 2.9 | 2.1 | 2.8 | 1.5 |
a Vss for UK-390957 was 398 ± 75 liters (mean ± S.D.; n = 15 individuals); mean body weight for the individuals was 76.7 kg.
b A blood/plasma concentration ratio of 3.5 was used in the calculation because plasma concentrations were <100 ng/ml in the clinical study with UK-390957.