Compound | Km | Vmax | Pdiff | CLactive | CLactive/CLuptake |
---|---|---|---|---|---|
μM | pmol/min/106 cells | μl/min/106 cells | % | ||
Atorvastatin | 4.03 ± 4.01 | 1340 ± 320 | 5.35 ± 3.79 | 1500 ± 1980 | 98.5 |
Bosentan | 5.24 ± 1.56 | 105 ± 85 | 17.5 ± 4.4 | 18.7 ± 12.6 | 48.9 |
Cerivastatin | 5.17 ± 4.78 | 804 ± 168 | 23.7 ± 6.4 | 285 ± 247 | 86.7 |
Clarithromycin | 58.0 ± 47.9 | 2770 ± 2470 | 10.9 ± 4.1 | 50.7 ± 16.4 | 81.8 |
Erythromycin | 42.9 ± 13.9 | 520 ± 359 | 12.2 ± 4.4 | 11.4 ± 5.8 | 47.7 |
Fexofenadine | 7.41 ± 439 | 885 ± 474 | 6.75 ± 2.48 | 167 ± 126 | 94.3 |
Nateglinide | 4.83 ± 1.27 | 834 ± 373 | 16.6 ± 7.9 | 179 ± 96 | 90.7 |
Olmesartan | 53.0 ± 28.8 | 514 ± 326 | 0.863 ± 0.664 | 10.6 ± 4.2 | 92.1 |
Pitavastatin | 6.30 ± 5.06 | 1070 ± 960 | 18.8 ± 11.8 | 197 ± 121 | 87.9 |
Pravastatin | 30.5 ± 26.6 | 789 ± 385 | 1.67 ± 1.02 | 31.7 ± 10.4 | 95.1 |
Repaglinide | 2.98 ± 1.28 | 804 ± 346 | 58.2 ± 44.2 | 299 ± 122 | 84.6 |
Ritonavir | 2.62 ± 1.84 | 2160 ± 1530 | 118 ± 29 | 873 ± 216 | 87.5 |
Rosuvastatin | 6.05 ± 5.43 | 1250 ± 400 | 7.08 ± 3.23 | 418 ± 319 | 97.7 |
Saquinavir | 51.7 ± 21.0 | 12,000 ± 7700 | 191 ± 24 | 239 ± 152 | 52.1 |
Telmisartan | 3.85 ± 1.18 | 2220 ± 670 | 28.1 ± 10.0 | 630 ± 286 | 94.5 |
Valsartan | 12.3 ± 13.0 | 217 ± 220 | 3.91 ± 2.32 | 30.1 ± 32.4 | 79.4 |