Blood glucose levels in 10 healthy volunteers after a single oral dose of 0.25 mg of repaglinide, which was administered 1 h after placebo or a single oral dose of 30, 100, 300, or 900 mg of gemfibrozil
Values are mean ± S.D.
| Variable | Control | Gemfibrozil Dose | |||
|---|---|---|---|---|---|
| 30 mg | 100 mg | 300 mg | 900 mg | ||
| Baseline concentration (mmol/l) | 5.1 ± 0.6 | 5.0 ± 0.6 | 5.2 ± 0.8 | 5.0 ± 0.6 | 5.3 ± 0.5 |
| Minimum concentration (mmol/l) | 3.6 ± 0.4 | 3.5 ± 0.6 | 3.1 ± 0.5* | 3.3 ± 0.5* | 2.7 ± 0.6***,††,¶ |
| Mean concentration from 0 to 3 h (mmol/l) | 4.9 ± 0.5 | 4.7 ± 0.5 | 4.5 ± 0.3† | 4.4 ± 0.4** | 4.3 ± 0.5**,† |
| Mean concentration from 0 to 9 h (mmol/l) | 4.8 ± 0.4 | 4.8 ± 0.4 | 4.6 ± 0.3† | 4.4 ± 0.4*,†† | 4.2 ± 0.5***,†† |
* P < 0.05 vs. control;
** P < 0.005 vs. control;
*** P < 0.001 vs. control;
† P < 0.05 vs. 30 mg;
†† P < 0.005 vs. 30 mg;
¶ P < 0.05 vs. 300 mg.